Marco Santin and Giorgio Gherarducci - supported in the studio by Mago Forest, a great cast of comedians and many surprise guests - comment with biting irony on the most popular TV programs, the main sporting events and the last web trends.

When Alessandra and Emilio move to the city leaving their parents Carlo and Anna alone, life changes for everyone. The once close-knit family is now fractured, with the kids forgetting about their parents and missing out on important family events. However, the breaking point for the parents comes when they realize their children won't be with them for Christmas.

After getting tired of his corporate job in Milan, a person decides to leave it all behind and pursue his dream of opening a beach bar in Sardinia. Along the way, he encounters various challenges and comedic situations.

In Mi fido di te, a man who is down on his luck and in debt puts his trust in a scam artist to help him make money. They come up with a plan to fake the man's suicide in order to collect insurance money, but things go awry when the man's ex-girlfriend recognizes him. As they try to escape from her, they get caught up in a series of humorous and chaotic events involving a stolen car, a gypsy fortune teller, a recording company, and a robbery at a supermarket.

65 year old doctor Pierfrancesco works as a night-shift medical guard. He’s a grumpy man, full of aches and pains and is very rough with his patients. One night, he’s involved in a road collision with 30 year old delivery man Mario. While uninjured, Mario's bicycle is destroyed, and Pierfrancesco's sciatica flares up, making it impossible for him to drive. With both of their jobs in jeopardy, the doctor has an idea that could help them both: “remotely guided” by Pierfrancesco via wireless headset, Mario will visit his patients, and they’ll also carry out Mario’s delivery in Pierfrancesco’s car. After a range of daring (mis)adventures, they will learn to support each other, and the night will end with their lives both changed for the better.