U Me Aur Hum follows the story of Ajay and Piya, a married couple who embark on a cruise together. However, their lives take an unexpected turn when Piya is diagnosed with a mental illness. Ajay, who is also a psychiatrist, must navigate the challenges of his wife's condition while trying to keep their love and marriage intact. The movie explores themes of love, disease, and the power of storytelling to heal.
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