Tenacious D in The Pick of Destiny (2006)

To become the greatest band of all time, two slacker, wannabe-rockers set out on a quest to steal a legendary guitar pick that gives its holders incredible guitar skills, from a maximum security Rock and Roll museum. As they embark on their journey, they encounter comedic mishaps and challenges while discovering the secrets of rock legends. Along the way, they learn the power of friendship and the true meaning of rock 'n' roll.