Monstrosity (1963)

In 'Monstrosity,' a mad scientist performs brain transplant experiments in order to attain eternal youth. His experiments involve transplanting brains from young women into old bodies, and vice versa. Things take a sinister turn when a young woman who uses a wheelchair becomes involved in the experiments. The scientist's mansion becomes a hub of betrayal, secrecy, and murder as his desperate quest for eternal youth spirals out of control.