Blade: Trinity (2004)

Blade, now a wanted man by the FBI, must join forces with the Nightstalkers to face his most challenging enemy yet: Dracula. After Whistler sacrifices himself, Blade is captured by the FBI but is saved by the Nightstalkers. Together, they discover that Dracula has been reawakened by the vampires to help with their final solution. Blade and the Nightstalkers must stop Dracula and his vampire army with the help of a new weapon, the DayStar virus.