At the end of his career, a clueless fashion model is brainwashed to kill the Prime Minister of Malaysia. Follow Big John, a struggling model, navigating the cruel and dangerous fashion industry as he strives to become the most talked about and highest paid model. When his colleagues are killed, Derek Zoolander announces his retirement and attempts to reconnect with his family. However, fashion mogul Jacobim Mugatu offers Derek a chance to return to the runway and be brainwashed to assassinate the Prime Minister. As Derek becomes suspicious, he teams up with journalist Matilda to uncover the fashion industry's sinister plot.

Male model Derek Zoolander is forced to return to the world of fashion when an unknown assassin begins targeting the industry's iconic figures. With the help of his former rival, Hansel, and a newcomer named Valentina Valencia, they must unravel the mystery and stop the criminal plot before it's too late.