In the town of Seabrook, zombies and humans coexist. When a zombie and a cheerleader fall in love, they try to bring the town together through their musical talents.

High schoolers Zed and Addison are preparing for their respective goals: Zed's athletic scholarship and Addison's cheerleading competition. However, their plans are derailed when extraterrestrial beings invade their town of Seabrook. To protect their true mission, Zed and Addison pretend to participate in the cheer competition while uncovering secrets about each other, including the possibility of Addison being an alien. As they face the challenges of the invasion, love, and self-discovery, they must also ensure the aliens don't find a crucial map. Will they succeed and find their true selves?

In Z-O-M-B-I-E-S 2, the love story between a zombie and a cheerleader continues as they face challenges such as a love triangle, integration issues, and a school bus accident. The movie explores themes of equality, racism, and acceptance while featuring musical numbers, comedy, and romance.

Zed and Addison embark on a road trip the summer after their first year of college. As adventures unfold, they unexpectedly discover the warring worlds of Sunnyside and Shadyside and come into contact with two new groups of monsters.