In 1923 the scientist Von Dracula invented Vampisol, a drink that allowed vampires to live in the sun. La Capa Nostra and the European Vampire Group confront each other in Havana to control the Vampisol, but Pepe, Von Dracula's nephew, sang the Vampisol formula for free on Radio Vampiro Internacional. Now Pepe must face the Nazi vampires, who use the most powerful Vampisol: El Vampiyaba.

Vampires in Havana is a dark comedy that follows the adventures of a trumpet player who gets caught up in a battle between vampires and the mafia in Havana. With adult humor, sexual tension, and plenty of laughs, this film is perfect for grown-ups who love animation.