Ami and David, on their way home, hit a raccoon and damage their car. They stay at a motel where they find snuff films shot in the same room. They try to escape but are stopped by the Manager of the Motel and his two killer side-kicks. Ami manages to call 911, but the old policeman sent to help is promptly killed. David is stabbed, and Ami escapes with a BMW, running over one killer and shooting the motel manager. She finds David still alive.

Vacancy 2: The First Cut is a crime horror thriller film that follows a young couple who check into a motel and unknowingly become part of a snuff film. They must fight for their lives as they try to escape the sadistic killers.