In a desperate search to create a follow-up to Joe Swanberg's 2011 film Uncle Kent, Kent Osborne travels to a comic book convention in San Diego where he loses his mind and confronts the end of the world.

Uncle Kent is a comedy-drama film about an introverted cartoonist named Kent Osborne who has a weekend filled with sexual misadventures. When a houseguest named Kate visits, things take a turn as they explore their unrequited lust and engage in a threesome. Throughout the film, Kent navigates through loneliness, online dating, and his own introspective journey.