After Professor McBride learns that the body of his daughter Julie was never found, he takes it upon himself to go on a quest to discover the truth about his daughter's disappearance. With the help of Chava, a young Mexican anthropologist and a cult of old witch ladies, he embarks on a mission to exorcise the body of Julie from the evil soul of La Llorona.

Daniel and Alice take their two young children to Alice's mother's house after the tragic and mysterious death of her father. Once there, Daniel learns about several unresolved murder and missing people cases. Daniel and his family also become victims of this town's dark faith when his wife mysteriously dies and his children go missing. Soon after this tragedy he begins to investigate what's haunting the town and its residents. In his research he discovers that his wife is a direct descendant of a women known as "La Llorona", the troubled mother who drowned her children after her husband's infidelity centuries ago. "La Llorona's" tortured should haunts everyone and her insatiable thirst for blood will destroy everyone in her path.

On their way to Mexico, six students are stranded in a small town where years before a tragedy took place.