In modern-day San Francisco, reporter Daniel Molloy interviews Louis De Pointe Du Lac, who claims to be a vampire. Louis recounts his life as a wealthy plantation owner in 18th-century Louisiana. After being turned into a vampire by Lestat De Lioncourt, Louis struggles with his instinct to kill and feeds on animal blood instead. He saves a dying girl named Claudia and raises her as his daughter. When Claudia realizes she will never age, she kills Lestat and they flee to Paris. There, they encounter other vampires and are eventually punished for Lestat's murder. Louis sets the theater on fire, killing all the vampires. Decades later, Louis encounters a weakened Lestat and rejects his offer to join him. He concludes his interview with Molloy before disappearing. Molloy is attacked by Lestat, who offers him the choice to become a vampire.

In this horror/fantasy film, a vampire rock star named Lestat rises from his slumber and becomes a global sensation with his music. As his fame grows, he threatens to unleash his supernatural powers upon the world, causing chaos and destruction. A group of humans, including a powerful vampire queen, must stop him before it's too late. With a mix of death, rock music, and supernatural elements, Queen of the Damned is a thrilling and dark tale of power and obsession.