Big Deal on Madonna Street is a lighthearted crime drama about a group of small-time crooks who plan an attempted burglary. The film explores their various misadventures and the challenges they face as they try to carry out the heist. Filled with humor and social commentary, Big Deal on Madonna Street combines elements of neorealism with satirical parody.

Fresh out prison, Tiberio reconnects with his old partners in crime, Michele Ferribote and Peppe the Panther, only to realise that a lot has changed--including crime--after twenty years. Can he cope with this new reality?

A crew of aging gangsters in Milan, Italy plan and execute a successful heist on a bank vault using a clever scheme. The story follows their recruitment of a petty thief, their encounters with the police and the carabinieri, and their hilarious escapades throughout the city.