Four teenage girls, Lena, Tibby, Carmen, and Bridget, who have been best friends since they were born, are about to spend their first summer apart.

In "The Sisterhood of the Traveling Pants 2," four best friends find themselves facing new challenges and experiences during their summer break. The magical pair of pants that fits each of them perfectly continues to bring them closer, as they navigate through love, friendship, and personal growth. Bridging the distance between them, the girls share their triumphs and struggles through letters, discovering the true meaning of friendship and the power it has to shape their lives.