A religious mystery protected by a secret society is discovered after a murder in the Louvre. Clues lead to the existence of the Holy Grail and a secret that could undermine the teachings of the Roman Catholic Church.

When Robert Langdon wakes up in an Italian hospital with amnesia, he teams up with Dr. Sienna Brooks and they race across Europe together against the clock to foil a deadly global plot. They discover that a geneticist named Bertrand Zobrist wanted to unleash a virus worldwide to wipe out billions of people before his suicide. Langdon and Sienna must decipher clues left by Zobrist and stop the virus from spreading. Along the way, they encounter danger, betrayal, and moral dilemmas.

Harvard symbologist Robert Langdon teams up with a nuclear physicist to solve a murder and stop a terrorist act targeting the Vatican. The Illuminati, an underground secret society, kidnaps potential candidates for the papal conclave and threatens to destroy the Vatican with stolen antimatter. Langdon must solve the clues left by the Illuminati to save the four kidnapped individuals and prevent the catastrophic explosion.