Two zanies get mixed up with a Southern colonel, his beautiful daughters, a nightclub and a haunted mansion.

Ole Olsen and Chic Johnson are Broadway stars who return to Universal Studios to make another movie. The mere mention of Olsen and Johnson's names evacuates the studio and terrorizes the management and personnel. Undaunted, the comedians hire an assistant director and unknown talent, and set out to make their own movie.

Hellzapoppin' is a musical comedy film that follows the chaotic and anarchic adventures of a couple who find themselves in a demon-filled theater. Filled with slapstick comedy, singing, and vaudeville acts, the film is a riotous display of chaos and absurdity.

Ole and Chic are comedians employed in a nightclub, but seeking to be released from their contracts to take a better job. But the prissy nightclub owner, B. J. Wagonhorn, refuses to let them go. In reprisal, they start hurling insults at the nightclub patrons… a ploy that soon has them facing multiple lawsuits… to the delight of three struggling attorneys, Charlie Rodman, Bettty Wilson and Arthur Lane.