A covert team of immortal mercenaries is suddenly exposed and must now fight to keep their identity a secret just as an unexpected new member is discovered. Andromache of Scythia ("Andy"), Booker, Joe, and Nicky are centuries-old warriors with unexplained regenerative healing abilities who use their vast experience to work as mercenaries. They accept a job from former CIA operative James Copley to rescue a group of kidnapped girls, but their mission turns out to be a set-up. They are ambushed and killed, but quickly regenerate. Realizing they have been betrayed, they go after Copley while also finding and extracting a new immortal member named Nile Freeman. They must now face the forces sent by the pharmaceutical executive who wants to capture them and discover the secret to their immortality. With the help of Copley, they manage to free their captured teammates and defeat their enemies. In the end, they sentence Booker to loneliness for his betrayal and continue their mission to help the world in secret.

A sequel to 2020's 'The Old Guard'.