The Man from Earth: Holocene is a sequel to the 2007 film 'The Man from Earth.' It follows the story of John Oldman, a man who claims to be a prehistoric immortal being. As his secret is threatened to be exposed, he must confront the consequences of his immortality and navigate through philosophical and ethical dilemmas. The movie explores themes of identity, mortality, and the nature of humanity.

An impromptu goodbye party for Professor John Oldman becomes a mysterious interrogation after the retiring scholar reveals to his colleagues he has a longer and stranger past than they can imagine. John slowly reveals that he is the 'caveman' under discussion when he mentions that he was given a chance to sail with Christopher Columbus in the 15th century. As the film progresses, John reveals that he was once Jacques Borne, a friend of Van Gogh's, and he is now 'moving on' since some people have noticed his lack of aging. The tension between John and his colleagues rises, leading to a dramatic confrontation and ultimately, John deciding to spend some part of his life with Sandy.