In this sequel to The Last Exorcism, a young woman named Nell is found in the woods, traumatized and without any memory of the previous months. She is taken to a halfway house in New Orleans where she starts experiencing supernatural occurrences once again. As the evil force that possessed her in the past returns, Nell must confront her past and find a way to survive the exorcism once more.

A fraudulent exorcist, Reverend Cotton Marcus, agrees to let a documentary crew film his final exorcism. However, he soon realizes that the possessed girl he is dealing with is genuinely possessed by an evil spirit. As the exorcism progresses, Reverend Marcus and the crew find themselves in danger as they uncover dark secrets and face off against a satanic cult.