An FBI Agent persuades a social worker, who is adept with a new experimental technology, to enter the mind of a comatose serial killer in order to learn where he has hidden his latest kidnap victim. Child psychologist Catherine Deane is an expert in an experimental treatment for coma patients: a virtual reality device created by Dr. Henry West that allows her to enter the minds of individuals in a vegetative state and attempt to coax them into consciousness.

In The Cell 2, a psychic investigator with amnesia is brought back to life repeatedly to solve a serial killer case. She must use her clairvoyance to uncover the killer's twisted mind. As she delves deeper into the investigation, she faces mind control, torture, and danger at every turn. Will she be able to catch the killer before it's too late?