After Right, a petty criminal, kills Bhai's son, Bhai's gangsters seek revenge by killing Right's friend Balu. Later, Right decides to lead a normal life, but a corrupt police officer exploits him.

Thalainagaram 2 is the story of a formerly ruthless gangster who is now trying to live a peaceful life. However, his plans are disrupted when the three powerful criminals who control the city refuse to let him leave his past behind. As he battles against the odds, he must confront his fears and stand up for what is right.