When a kingpin threatens New York City, a group of mutated turtle warriors must emerge from the shadows to protect their home. They team up with a journalist named April O'Neil to uncover the truth behind the threat. As they fight against the ruthless Shredder and his Foot Clan, they must also navigate their own past and learn what it means to be heroes.

When Shredder joins forces with mad scientist Baxter Stockman, the Teenage Mutant Ninja Turtles must stop their old enemy and his mutant allies from unleashing a deadly toxin that will turn humanity into mutants. With the help of April O'Neil and vigilante Casey Jones, the turtles embark on an action-packed adventure to save New York City.