Super Size Me 2: Holy Chicken! is a documentary that delves into the unethical practices of the American food industry, particularly focusing on the fast food restaurant and processed food sectors. The film highlights the negative impact of these industries on public health, with a specific focus on the ill effects of consuming fast food regularly. The documentary also sheds light on the deceptive tactics used by the food industry to market their products and manipulate consumers. It aims to raise awareness about the detrimental effects of these industries on society.

Morgan Spurlock explores the health consequences of a diet consisting solely of McDonald's food for one month. Despite warnings from health professionals, Spurlock gains weight, experiences depression and lethargy, and even suffers heart palpitations. The experiment brings attention to the fast food industry and its impact on personal health.