Peter Parker, a high school student, becomes Spider-Man after being bitten by a genetically-altered spider. He uses his new spider-like abilities to fight crime and protect the city from the vengeful Green Goblin.

After a black alien symbiote bonds with Peter Parker, he must face inner turmoil and new challenges, including villains and revenge.

Peter Parker is beset with troubles in his failing personal life as he battles a former brilliant scientist named Otto Octavius. Peter struggles to balance his crime-fighting duties as Spider-Man with his normal life, which includes financial difficulties, relationship problems, and a strained friendship. Meanwhile, Doc Ock becomes a dangerous supervillain after a failed experiment. As Peter's personal and superhero lives collide, he must confront his own limits as a hero and face the consequences of his actions.