Peter Parker is beset with troubles in his failing personal life as he battles a former brilliant scientist named Otto Octavius. Peter struggles to balance his crime-fighting duties as Spider-Man with his normal life, which includes financial difficulties, relationship problems, and a strained friendship. Meanwhile, Doc Ock becomes a dangerous supervillain after a failed experiment. As Peter's personal and superhero lives collide, he must confront his own limits as a hero and face the consequences of his actions.

After a black alien symbiote bonds with Peter Parker, he must face inner turmoil and new challenges, including villains and revenge.

Peter Parker, a high school student, becomes Spider-Man after being bitten by a genetically-altered spider. He uses his new spider-like abilities to fight crime and protect the city from the vengeful Green Goblin.