Fifteen years ago, three childhood friends, Geki, Sherry and Okuma, were star-gazing and became inspired to go into space. As adults, Geki and Okuma join a mission to Mars, but their space shuttle goes missing before they could reach their destination. A year later, a monster attacks and a mysterious silver-colored warrior appears.

In Space Sheriff Shaider: THE NEXT GENERATION, a new hero rises to take on the space police duties, battling evil forces that threaten peace in the galaxy. With their advanced armor and weaponry, the new generation of Space Sheriffs must face various challenges, including rescuing kidnapped civilians and protecting innocent lives. As they navigate through a futuristic universe, they discover the true meaning of heroism and the power to stand up against darkness.

Kai Hyuga / Sharivan uncovers the existence of a spy from the Neo Madou organization. In addition to that Kai's friend, Seigi, becomes the new Space Sheriff Estevan. They must find the spy and stop a drug ring from shipping a pain suppressing narcotic called Hyper-M on Earth. But the new Space Sheriff must learn to trust his instincts and that not all is as it seems...