In South Park: Post COVID, the boys find themselves dealing with the aftermath of the COVID-19 pandemic. With a time jump into the future, they navigate a world changed by the virus and encounter absurd and hilarious situations along the way.

In the post-COVID future, the South Park residents deal with the consequences of the pandemic, a time-jump, and a mysterious turd. They navigate the challenges of a changed world and the ongoing effects of the pandemic, including COVID-lockdown and coronavirus quarantine. The story is filled with humor and satire.

In this South Park movie, the characters confront the return of the COVID-19 pandemic by using time-travel, leading to a series of absurd and comical situations involving urination, guns, blood, NFTs, COVID lockdown, marijuana cultivation, aluminum foil, pangolins, and coronavirus quarantine.