Romy and Michele are best friends who invent successful careers and relationships to impress their high school classmates at their reunion. Along the way, they encounter car trouble, blonde stereotypes, and learn the value of true friendship.

Romy and Michele, two best friends, leave their small town and head to Hollywood to reinvent themselves. Along the way, they encounter various adventures, including a nightclub mishap, dealing with high school drama, and discovering their true selves.