Serial killer Molly Keller, along with a few insane youngsters agrees to be a trail subject for an unconventional experiment. But, the experiment turns unsuccessful and the subjects begin to die.

Ripper: Letter from Hell is a horror movie about a group of friends who are terrorized by a mysterious killer on a college campus. As they are murdered one by one, the friends must unravel the mystery of the killer's identity and survive the night.