Larry is a divorced father who becomes a night security guard at a museum. He soon realizes that the exhibits come to life and wreak havoc. With the help of the museum's historical figures, Larry tries to regain control and save the museum from disaster.

Larry Daley, now a successful CEO, discovers that his museum exhibit friends have been shipped to the Smithsonian Institution. He goes on a mission to rescue them from an evil Pharaoh and his troops, using a magical tablet. Along the way, Larry meets historical figures and embarks on an adventure to save the world.

Larry Daley, the night watchman at the Museum of Natural History, must unite his favorite exhibits and go on an epic adventure to save the magic of the tablet. With the help of new characters and a journey across the globe, Larry faces chaos, unraveling mysteries, and the corrosion of the tablet that causes the exhibits to act abnormally. Together, they must retrieve the tablet's powers and restore harmony to the museum.