After defeating his superhero nemesis, Megamind creates a new villain who turns out to be a threat to humanity. Now, he must step up and use his genius to save the world.

Megamind's former villain team, The Doom Syndicate, has returned. Our newly crowned blue hero must now keep up evil appearances until he can assemble his friends (Roxanne, Ol' Chum and Keiko) to stop his former evil teammates from launching Metro City to the Moon.