Mean Girls 2 is a comedy film that follows the story of a teenage girl who gets caught up in a high school rivalry involving cliques, meanness, and misunderstandings. With a female protagonist and themes of friendship and popularity, the movie explores the challenges of teenage life.

Cady Heron enrolls in a new high school and befriends a group of popular girls called the Plastics. However, her plan to seek revenge on the group's leader, Regina George, backfires and she ultimately learns the importance of staying true to herself.