Manay Po tells the story of Luz, a small time jeweler who dreams of making it big so as to provide a better life for her family. Her life revolves around her brood of three, namely, Oscar, Orson and Orwell and her live-in boyfriend Gerry. With the help of her good friend and maid Maritess, Luz was able to raise her children normally despite the absence of a husband. In spite of her children's questionable sexualities, their family paints a picture of a happy family - a home filled with laughter and unconditional love.

Luzviminda Dimagiba (Cherry Pie Picache) and her three gay sons: Oscar (Polo Ravales), Orson (John Prats) and Orwell (Jiro Manio) are back! And now they want to add a new member to their outrageous family – a cute little baby to make their new home happy and complete! But babies don’t just really just fall from heaven or can be fetched from a river, so when the Dimagibas are figuring out this dilemma, Bette (Rufa Mae Quinto) – the ditzy baby maker just came right on time to provide the answer.