Living in the lawless Ishinari District in a future Japan, sisters Ami (Hina Nagimiya) and Yoshie (Hanakage Kanon) who sold their bodies to help their parents, try to earn a living performing as an idol group in the area. When their performance causes stranger Matsukata (Tak Sakaguchi) a notorious hitman, to notice their condition, the three realize their worth to each other in the fight against Aoyama Dharma (Kimono Negishi), the female boss of a notorious organ harvesting ring in the area. Realizing that even their skills are no match for her army of goons and henchmen, the two are outfitted with special homemade weaponry to their bodies and become the ultimate killers.

Ami's friend, Yoshie, was murdered and desecrated by the Kimura Gang. She was saved and, like Ami in the previous film, received modifications from the same mechanics. Remembering her past, Yoshie decides to avenge herself and Ami.

Ami, a high school girl, seeks vengeance after her brother is killed and she is attacked and dismembered by a Yakuza gang. Equipped with a machine gun arm, she goes on a killing spree to avenge her family.