In Machete Kills, the tough and fearless ex-Federale Machete is recruited by the U.S. government to stop a terrorist plot involving a powerful cartel leader and a nuclear missile. With over-the-top violence, stylized fights, and absurd humor, Machete must navigate through a world of assassins, villains, and femme fatales to save the day.

Voz flees to outer space after attempting to start a nuclear war on Earth and there is only one man who the President can trust to take Voz down: Machete.

After being betrayed by his former boss, an ex-Federale launches a brutal rampage of revenge against a Texas Senator. He must navigate through political corruption, immigration law, and his own personal loss to achieve his ultimate goal.