Lucky Luke is a skilled gunslinger who maintains peace in the wild west. He faces various challenges including shootouts, gunfights, and conflicts with settlers and outlaws. Along the way, he forms alliances with Native Americans and encounters a wide array of colorful characters.

Cowhairs want to drive farmers away from their lands. Luke takes matters into his own hands, and even Lotta's beauty and kindness can't hold him back. Signs suggest that there is also a third party in the background who benefits from the strife.