Young women disappear one after another in drizzling rain. They all hear the “cursed song” of the Cage Song before they vanish into thin air. Kitaro and his friends investigate these mysterious cases when they meet Kaede Hiramoto, a high school girl who finds herself involved in this mystery. With the help from the librarian of Yokai Library, they find out that the curse was caused by an evil Yokai that was released from 1,000 years of sealing. To save Kaede, they are to gather the 5 ancient musical instruments and perform the ritual to seal the evil Yokai again, which has to be done within 48 hours!

Kitaro is a half human, half creature who keeps an eye on the human society to save them from the evil attacks from another world. He finds that a magical ball that controls all powers had been brought into the human world, and stops it from falling into the wrong hands.