A police detective, a bank robber, and a high-power broker enter high-stakes negotiations after the criminal's brilliant heist spirals into a hostage situation. The robbers, dressed as painters, seize control of a bank and lock the hostages in various rooms. As the police surround the bank, the detectives discover the robbers' motives and true intentions. The situation escalates when the robbers release the hostages and detonate smoke bombs, leading to confusion and the discovery of a hidden safe deposit box. The detective refuses to bury the case and uncovers a larger conspiracy involving Nazi connections and stolen diamonds. Ultimately, the bank robber, known as the Inside Man, escapes with the stolen goods while leaving behind clues for the detective to follow.

Inside Man: Most Wanted follows a skilled criminal mastermind who orchestrates an elaborate bank heist and hostage situation. As negotiations between the police and the criminals intensify, a determined hostage negotiator races against time to uncover the truth behind the heist and bring the criminals to justice.