In the Siberian prison camp, Ilsa, the Tigress of Siberia, rules with an iron fist. She engages in sexual violence, torture, and sadism, showing no mercy to her prisoners. The film explores themes of nihilism, suffering, and sexual perversion.

Ilsa, the cruel leader of an oil-rich country, maintains a harem where women are held captive and subjected to her sadistic desires. When a group of rebels attempts to overthrow her, Ilsa uses her power to manipulate and control those around her. Amidst the violence and cruelty, a forbidden love affair arises, leading to unexpected consequences.

Greta, a sadistic prison warden, takes pleasure in inflicting sexual violence and torture upon her helpless victims. As she terrorizes the women in her custody, a female protagonist seeks revenge for the suffering she and others have endured. This erotic and brutal grindhouse film explores themes of sexual perversion, sadism, and the violent depths of human cruelty.

In Nazi Germany, the sadistic nurse Ilsa conducts brutal experiments on prisoners in a concentration camp. She seeks to prove certain theories of female sexual response and castration. Ilsa's reign of terror includes rape, torture, and murder, all in the name of sadism and Nazi ideology.