Scientist Dr. Sebastian Caine develops a serum that can make a subject invisible but has difficulty reversing the process. He becomes obsessed with his ex-girlfriend and conducts human testing on himself. The reversion fails, leading to aggression and hostility. Sebastian becomes invisible and goes on a killing spree, targeting his colleagues. The remaining team members realize they are the only ones who can stop him. They fight to survive as Sebastian hunts them down. In the end, Linda and Matt manage to kill Sebastian and escape the burning lab.

After turning invisible, a man uses his newfound powers to commit heinous acts and evade capture by the police. As he becomes more unhinged, a detective races against time to stop him.