In the Wild West, a group of female gunfighters known as the Gang of Roses seek revenge for the death of their sister. They face off against a corrupt sheriff and his gang in a series of intense shootouts and showdowns. With their long brown hair and fierce determination, these cowgirls show that they can hold their own in a world dominated by men.

Cassie, the last remaining member of the original Gang of Roses, is sitting in a small Mexican jail holding the written code to a US military safe. It s here that she meets Collette (Eurika Pratts), a young gambler looking for her next con. Kate (Rocsi Diaz) attempts to break her out, and Cassie is killed. Upon their return, Kate and Collette meet up with outlaws Candi (Teyana Taylor) and Mimi (Claudia Jordan). After some lengthy planning, the four women head to the Mexican town of San Juevo and prepare for the robbery, which will take place in the town church. But unbeknownst to them, they are being followed by Lee (Gabriel Casseus) and his posse of bandits, looking to ambush the women before they can make their big score.