An elite military unit known as G.I. Joe takes on an evil organization led by a notorious arms dealer. The arms dealer has created Nanomites, powerful weapons capable of destroying anything, and plans to use them for world domination. G.I. Joe must stop him and save the world from his sinister plans.

The G.I. Joes are forced to fight not only their mortal enemy Cobra but also threats from within the government. They must secure nuclear warheads from Pakistan and uncover a conspiracy that jeopardizes their existence. The Joes are blamed for stealing weapons and labeled traitors. They must stop Cobra from launching a destructive project, while avenging their fallen comrades. With the help of allies and their skills, the Joes fight to protect their country and save the world from chaos.