In Fritz the Cat, the eponymous feline protagonist navigates his way through the sexual revolution and political commentary of 1960s New York City, experiencing surreal adventures and encounters with anthropomorphic characters, while addressing themes of social satire, racial tension, and urban violence. The film contains explicit sexual humor, profanity, and scenes of sexual violence.

The film follows Fritz the Cat, a hedonistic and rebellious feline who embarks on a series of misadventures that explore themes of sexuality, race, and societal norms.