In "Escape Room: Tournament of Champions," the survivors from the previous escape room challenge find themselves forced to participate in a new deadly competition. They must navigate a series of intricately-designed rooms filled with puzzles and traps, using their wits and teamwork to stay alive. As they uncover dark secrets and face their own fears, the stakes become higher than ever before.

Six strangers find themselves in a deadly maze of mystery rooms and must use their wits to survive. A man tries to escape a collapsing room by solving a puzzle. Zoey, Ben, and Jason receive puzzle boxes and are invited to the Minos Escape Room for a chance at $10,000. They are joined by Amanda, Mike, and Danny. In the rooms, they face deadly challenges and discover that the game is connected to their past traumas. As they progress, they learn the true purpose of the game and fight to escape and expose the secrets. Zoey and Ben manage to survive and defeat the Gamemaster. Six months later, they are lured into another game by the game's architect.