After 20 years, Lloyd and Harry embark on a road trip to locate Harry's newly found daughter, who was given up for adoption. The motive behind their mission is to ask the daughter for a kidney transplant, as Harry is having kidney problems. With their usual stupidity and slapstick comedy, the two friends set out on an adventurous journey filled with mistaken identities, hilarious mishaps, and outrageous encounters.

Lloyd Christmas and Harry Dunne embark on a hilarious cross-country trip to return a briefcase left at the airport, facing a series of misadventures along the way.

Harry and Lloyd, two dim-witted friends, get into ridiculous situations as they try to return a briefcase full of money to its rightful owner.