In Doom: Annihilation, a group of space marines are sent to a research facility on Mars where they must fight off hordes of demons. As they uncover the dark secrets of the facility, they must find a way to survive and prevent the demons from escaping to Earth.
In the year 2046, a team of Space Marines is sent to investigate mysterious happenings at a research facility on Mars. They discover that the scientists have been attacked by genetically enhanced creatures. As they fight for their survival, they uncover the truth about the creatures' origins and abilities.