A sorcerer tears pages from a book and escapes with the help of his followers. Renowned surgeon Dr. Strange, after a car accident, loses the ability to use his hands. He travels to Nepal and learns about the mystical world from the Ancient One. Strange trains in Kamar-Taj and discovers the existence of other dimensions. A former student of the Ancient One, Kaecilius, steals a spell and plans to call in Dormammu from the Dark Dimension to take over the world. Strange must use his newfound powers to stop him and protect Earth.

Doctor Strange teams up with a teenage girl who can travel between dimensions to battle threats across the multiverse. They seek help from Wanda the Scarlet Witch, Wong, and others.