In a dystopian future, the United States is ruled by a dictator, and the most popular sport is a deadly cross-country race where racers score points by killing pedestrians. Frankenstein, the reigning champion, is targeted by resistance fighters and must navigate dangerous obstacles to win.

In the year 2050, the government organizes a car race where the objective is to kill as many competitors as possible. The race takes place in a world overpopulated and controlled by corporations. Death, mayhem, and murder are constant in this grindhouse-style competition, filled with black humor and political satire. As the race progresses, a female spy and femme fatale navigate the dangerous landscape while a child in a wheelchair is in jeopardy. With voyeurism, passionate kisses, and provocative scenes, Death Race 2050 offers a thrill ride like no other.