Criminally Insane 2 follows the story of a delusional woman who becomes a psycho killer, using a meat cleaver to murder her victims. As an obese woman, she struggles with mental illness and delusional disorder. This horror thriller movie explores themes of obesity, psychiatric patients, and the consequences of delusional thinking.

Criminally Insane tells the story of an overweight woman named Ethel who becomes a psychotic killer after the death of her grandmother. Unable to control her homicidal urges, Ethel goes on a killing spree using a meat cleaver and preying on unsuspecting victims. As the body count rises, Ethel's mental illness and obsession with food lead her down a path of gore and insanity.