In Clown Motel: Spirits Arise, a group of ghost hunters venture into an abandoned motel infested with supernatural serial killers in the form of evil clowns. As they explore the motel, they encounter gruesome murders, dismemberments, and supernatural powers. The group must fight for their lives and face the ghosts of the past to survive.

A group of people, led by Brooke's fiance, embark on a search for her in the Clown realm where she and Jane Doe have been trapped.