In City Slickers II: The Legend of Curly's Gold, a group of friends reunite to search for hidden gold in Nevada. They face challenges and dangers throughout their journey, including mistaken identities and attempts to murder them. Along the way, they also navigate their relationships and bond as they navigate through the wild west.

Three friends in the midst of mid-life crisis embark on a cattle drive adventure in the West, hoping to find purpose and escape their mundane lives. Together, they navigate the challenges of the wilderness, learning about friendship, personal growth, and the value of embracing new experiences.